I strongly recommend suppressing the first phrase of point 3
We surmise that results obtained from the experiments described in this section cannot serve to understand the role of INaL in arrhythmogenesis.
1. Van Driessche W, Lindemann B: Amount dependency regarding currents by way of single sodium-selective pores for the frog skin. Nature. 1979; 282 (5738): 519-520 PubMed Conceptual | Writer Complete Text message
It indicates the good findings put forward through this manuscript is maybe not justified and i try not to accept brand new manuscript contained in this means
The latest authors have explained a number of the questions I elevated during the my personal prior comment. Regrettably, most of the big difficulties have not been treated from this inform. When i made in my personal prior comment, We consider they unlikely that men and women activities might be repaired simply of the several additional sentences. Instead you can still find specific basic concerns toward fresh design and you can, most vitally, with the data.
This means this new strong results submit through this manuscript are perhaps not warranted and that i dont approve the new manuscript within means
The authors enjoys made clear several of the concerns I raised for the my personal previous review. Regrettably, every big troubles haven’t been addressed by this enhance. Whenever i stated in my personal earlier remark, We deem they unlikely that all men and women points might be solved only by the a number of additional sentences. Alternatively there are certain simple inquiries towards experimental construction and you may, very vitally, with the analysis.
- The best concern is that if I adopted the latest description out of the ways in the last variation it had been possible so you’re able to decode, which have almost prime precision, one arbitrary stimulus brands We chosen. See to have types of this reanalysis. Regardless of whether we pretend your actual stimuli seemed during the an afterwards time otherwise was consistently changing anywhere between code and you will quiet, the decryption is close to primary. This will be an indicator the decryption has nothing to complete into the genuine stimuli read of the Sender it is opportunistically exploiting some other keeps on the analysis. New handle data the fresh new experts did, treating the brand new stimuli brands, never target this problem as it is afflicted with alike disease. Essentially, what the classifier is presumably using is the time who may have passed as recording started.
- The reason for this is certainly presumably that article writers used low-independent analysis to have training and you can investigations. Whenever I know truthfully (find section 3), haphazard testing one half of information trials of an EEG trace commonly separate studies. Repeating the analysis 5 times the handle studies this new article authors performed isnt a sufficient cure for address this question. At random seeking samples off a period series with which has sluggish change (for instance the sluggish trend craft that presumably dominates this type of recordings significantly less than these circumstances) usually usually include strong temporal correlations. Find TemporalCorrelations.jpg in for 2D thickness histograms and you may a relationship matrix proving it.
- Just like the modified tips area brings more detail now, it still is unclear about exactly what research were used. Conventional classification data report just what study have (common columns throughout the study matrix) and you may exactly what observations (common rows) were used. Some thing might possibly be a component but typically this might be the fresh new some other EEG channels otherwise fMRI voxels etcetera. Observations are big date products. Here I assume this new people switched the brand new raw trials to your good more space using dominant role research. This is not said in case your dimensionality try quicker with the eigenvalues. In either case, I suppose the information and knowledge examples (obtained during the 128 Hz) was indeed upcoming utilized given that observations and also the EEG streams turned of the PCA were utilized just like the has actually. This new stimuli names had been assigned since the With the or Off for every single sample. A set of fifty% away from samples (and brands) was then selected at random having education, and the people was used to have assessment. So is this best?
